The Human Genome Project (or HGP) was a pioneering, major effort in the 1990's to develop a complete reference model of the human genome. It was a large, collaborative effort spanning many institutions across the world. Most of the work was conducted using CE based Sanger Sequencing.
Upon the major completion and wrap-up by 2003, there were still hundreds of gaps and nearly 10% of the suspected full genome not yet defined. In addition, it was mainly based on a few contributors, one in particular, and so really a reference to a single, western European descent male.
The immediate follow-on efforts are both the 1000 Genomes project to look at full sequencing over 1,000 people to compare and contrast, and the Genome Reference Consortium - humans (GRCh). Now, there are many parallel efforts, as NGS technology costs have dropped dramatically, to get 100,000 to 1 million sequences from which to build more diverse reference models across larger groups of the general population.
Upon the major completion and wrap-up by 2003, there were still hundreds of gaps and nearly 10% of the suspected full genome not yet defined. In addition, it was mainly based on a few contributors, one in particular, and so really a reference to a single, western European descent male.
The immediate follow-on efforts are both the 1000 Genomes project to look at full sequencing over 1,000 people to compare and contrast, and the Genome Reference Consortium - humans (GRCh). Now, there are many parallel efforts, as NGS technology costs have dropped dramatically, to get 100,000 to 1 million sequences from which to build more diverse reference models across larger groups of the general population.